Cancer immunotherapy works only when:
- Tumor cells are recognized as foreign by the host immune system
- Cytotoxic T-cells are activated
Mutations that activate T-cell immune responses
Mutations that are recognized by the immune system.
Why are T-cell neo-epitopes important?
- Predict efficacy of cancer immunotherapy drugs
- Enable patient selection
- Predict patient outcome
OncoPept platform integrates robust molecular profiling capabilities, combined with accurate data analysis to generate insights for better selection of T-cell neo-epitopes.
1. Molecular Profiling
Exome sequencing RNA sequencing
2. Data Analysis
Somatic mutation calling Expression level of mutant genes HLA typing
3. T-cell neo-epitope discovery
Generating a library of wild-type and mutant peptides HLA binding (multiple algorithms) Motif analysis Peptide processing